Correction of Copper Deficiency Improves Erythropoietin Unresponsiveness in Hemodialysis Patients with Anemia

Terumi Higuchi; Yoshihiro Matsukawa; Kazuyoshi Okada; Osamu Oikawa; Toshio Yamazaki; Yoshihiko Ohnishi; Takayuki Fujita; Noboru Fukuda; Masayoshi Soma; Koichi Matsumoto

doi:10.2169/internalmedicine.45.1541

CASE REPORTS

Correction of Copper Deficiency Improves Erythropoietin Unresponsiveness in Hemodialysis Patients with Anemia

Terumi Higuchi, Yoshihiro Matsukawa, Kazuyoshi Okada, Osamu Oikawa, Toshio Yamazaki, Yoshihiko Ohnishi, Takayuki Fujita, Noboru Fukuda, Masayoshi Soma, Koichi Matsumoto

Author information

Terumi Higuchi
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine
Yoshihiro Matsukawa
Division of Hematology and Rheumatology, Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
Kazuyoshi Okada
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine
Osamu Oikawa
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine
Toshio Yamazaki
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine
Yoshihiko Ohnishi
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine
Takayuki Fujita
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine
Noboru Fukuda
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine
Masayoshi Soma
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine
Koichi Matsumoto
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine

Keywords: copper deficiency, anemia, enteral nutrition, erythropoietin

JOURNAL OPEN ACCESS

2006 Volume 45 Issue 5 Pages 271-273

DOI https://doi.org/10.2169/internalmedicine.45.1541

Details

Abstract

We have encountered five hemodialysis patients who had received enteral nutrition and recovered from erythropoietinresistant anemia with neutropenia after the correction of copper deficiency. We reduced the required doses of recombinant human erythropoietin (rHuEPO) to maintain the target hematocrit levels and three patients were finally weaned from the rHuEPO therapy. Thus, copper deficiency is involved in erythropoietinresistant anemia in hemodialysis patients.

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