Beneficial Effect of Polymyxin B-immobilized Fiber Column (PMX) Hemoperfusion Treatment on Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Yoshitsugu Seo; Shinji Abe; Misuzu Kurahara; Daisuke Okada; Yoshinobu Saito; Jiro Usuki; Arata Azuma; Kiyoshi Koizumi; Shoji Kudoh

doi:10.2169/internalmedicine.45.6018

ORIGINAL ARTICLES

Beneficial Effect of Polymyxin B-immobilized Fiber Column (PMX) Hemoperfusion Treatment on Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Yoshitsugu Seo, Shinji Abe, Misuzu Kurahara, Daisuke Okada, Yoshinobu Saito, Jiro Usuki, Arata Azuma, Kiyoshi Koizumi, Shoji Kudoh

Author information

Yoshitsugu Seo
The 4th Department of Internal Medicine, Nippon Medical School
Shinji Abe
The 4th Department of Internal Medicine, Nippon Medical School
Misuzu Kurahara
The 4th Department of Internal Medicine, Nippon Medical School
Daisuke Okada
Aizu Chuo Hospital
Yoshinobu Saito
The 4th Department of Internal Medicine, Nippon Medical School
Jiro Usuki
The 4th Department of Internal Medicine, Nippon Medical School
Arata Azuma
The 4th Department of Internal Medicine, Nippon Medical School
Kiyoshi Koizumi
The 2nd Department of Surgery, Nippon Medical School
Shoji Kudoh
The 4th Department of Internal Medicine, Nippon Medical School

Keywords: acute exacerbation of idiopathic pulmonary fibrosis, polymyxin B-immobilized fiber column (PMX) treatment, alveolar-arterial difference of oxygen (AaDO₂), KL-6, lactate dehydrogenase (LDH)

JOURNAL OPEN ACCESS

2006 Volume 45 Issue 18 Pages 1033-1038

DOI https://doi.org/10.2169/internalmedicine.45.6018

Details

Abstract

Objective: This study was aimed to investigate the effect of polymyxin B-immobilized fiber column (PMX) hemoperfusion treatment on the acute exacerbation of idiopathic pulmonary fibrosis (IPF).
Patients and Methods: Six patients with a clinical diagnosis of idiopathic pulmonary fibrosis (IPF) who developed acute exacerbation were included in this study. Although five of six patients were treated with high-dose corticosteroid therapy, mechanical ventilation was necessary for all six patients due to severe respiratory failure. Blood endotoxin levels were undetectable in all patients. PMX treatment was performed on these six patients.
Results: In four of six patients, alveolar-arterial difference of oxygen (AaDO₂), serum KL-6 and lactate dehydrogenase (LDH) were improved after PMX treatment. These four patients were successfully weaned from mechanical ventilation and survived more than 30 days after the initial PMX treatment.
Conclusion: These data suggest a potential beneficial effect of PMX treatment on acute exacerbation of IPF.

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