Idiopathic Yellow Nail Syndrome Successfully Treated with OK-432

Toru Yamagishi; Nobuyuki Hatanaka; Hirotaka Kamemura; Ichiro Nakazawa; Yusuke Hirano; Norio Kodaka; Atsuo Miura; Asako Kitahara; Tetsuro Sawata; Kimio Hosaka; Ken Sanno

doi:10.2169/internalmedicine.46.0022

CASE REPORTS

Idiopathic Yellow Nail Syndrome Successfully Treated with OK-432

Toru Yamagishi, Nobuyuki Hatanaka, Hirotaka Kamemura, Ichiro Nakazawa, Yusuke Hirano, Norio Kodaka, Atsuo Miura, Asako Kitahara, Tetsuro Sawata, Kimio Hosaka, Ken Sanno

Author information

Toru Yamagishi
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Nobuyuki Hatanaka
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Hirotaka Kamemura
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Ichiro Nakazawa
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Yusuke Hirano
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Norio Kodaka
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Atsuo Miura
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Asako Kitahara
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Tetsuro Sawata
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Kimio Hosaka
Department of Respiratory Medicine, Toho University Ohashi Medical Center
Ken Sanno
Department of Respiratory Medicine, Toho University Ohashi Medical Center

Keywords: chemical pleurodesis, lymphedema, OK-432, pleural effusion, yellow nail

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 14 Pages 1127-1130

DOI https://doi.org/10.2169/internalmedicine.46.0022

Details

Abstract

A 70-year-old female presented with yellow discoloration of the nail beds of all fingers and toes, as well as bilateral pleural effusions. The patient was diagnosed as having the yellow nail syndrome based on the triad of yellow nails, lymphedema, and pleural effusions. The patient's intractable bilateral pleural effusion was treated with pleurodesis using OK-432. The treatment prevented the accumulation of pleural fluid for a long period of time. Pleural effusion associated with yellow nail syndrome is thought to be difficult to treat; however, this patient's excellent clinical course suggests that pleurodesis with OK-432 could be used to treat the disease in the future.

Corresponding author

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