IgG4-related Autoimmune Prostatitis: Two Cases with or without Autoimmune Pancreatitis

Isao Nishimori; Takuhiro Kohsaki; Saburo Onishi; Taro Shuin; Shino Kohsaki; Yasuhiro Ogawa; Manabu Matsumoto; Makoto Hiroi; Hideaki Hamano; Shigeyuki Kawa

doi:10.2169/internalmedicine.46.0452

CASE REPORTS

IgG4-related Autoimmune Prostatitis: Two Cases with or without Autoimmune Pancreatitis

Isao Nishimori, Takuhiro Kohsaki, Saburo Onishi, Taro Shuin, Shino Kohsaki, Yasuhiro Ogawa, Manabu Matsumoto, Makoto Hiroi, Hideaki Hamano, Shigeyuki Kawa

Author information

Isao Nishimori
Department of Gastroenterology and Hepatology, Kochi Medical School
Takuhiro Kohsaki
Department of Gastroenterology and Hepatology, Kochi Medical School
Saburo Onishi
Department of Gastroenterology and Hepatology, Kochi Medical School
Taro Shuin
Department of Urology, Kochi Medical School
Shino Kohsaki
Department of Diagnostic Radiology and Radiation Oncology, Kochi Medical School
Yasuhiro Ogawa
Department of Diagnostic Radiology and Radiation Oncology, Kochi Medical School
Manabu Matsumoto
Laboratory of Diagnostic Pathology, Kochi Medical School
Makoto Hiroi
Laboratory of Diagnostic Pathology, Kochi Medical School
Hideaki Hamano
Department of Medicine, Gastroenterology, Shinshu University School of Medicine
Shigeyuki Kawa
Center for Health, Safety and Environmental Management, Shinshu University

Keywords: autoimmune pancreatitis, prostatitis, IgG4-related sclerosing disease, positron emission tomography with [¹⁸F] fluorodeoxyglucose, steroid therapy

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 24 Pages 1983-1990

DOI https://doi.org/10.2169/internalmedicine.46.0452

Details

Abstract

Recently, autoimmune pancreatitis (AIP) has been reported with a variety of extra-pancreatic manifestations and infiltration of IgG4-positive cells into the affected organs. We report herein two cases with prostatitis. One was seen in a patient with typical AIP, and the other was observed without any clinical manifestation of AIP. Serum IgG4 levels were elevated in both cases. Histological examination of the prostates showed that parenchymal cells were partially or totally replaced with fibrosis and abundant infiltration of IgG4-positive cells. Significant uptake of [¹⁸F] fluorodeoxyglucose by the prostate was seen in both cases. In the case with AIP, the uptake completely disappeared after steroid therapy. The findings observed in these cases suggest that the pathological mechanism for prostatitis is similar to the mechanism previously implicated in AIP, namely IgG4-related autoimmune prostatitis.

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