A Juvenile Case of Cushing's Disease Incidentally Discovered with Multiple Bone Fractures

Ai Yoshihara; Yumiko Okubo; Akiyo Tanabe; Akira Sata; Momoko Nishimaki; Takakazu Kawamata; Osami Kubo; Tomokatsu Hori; Kazue Takano

doi:10.2169/internalmedicine.46.1824

CASE REPORTS

A Juvenile Case of Cushing's Disease Incidentally Discovered with Multiple Bone Fractures

Ai Yoshihara, Yumiko Okubo, Akiyo Tanabe, Akira Sata, Momoko Nishimaki, Takakazu Kawamata, Osami Kubo, Tomokatsu Hori, Kazue Takano

Author information

Ai Yoshihara
The Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University
Yumiko Okubo
The Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University
Akiyo Tanabe
The Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University
Akira Sata
The Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University
Momoko Nishimaki
The Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University
Takakazu Kawamata
the Department of Neurosurgery, Tokyo Women's Medical University
Osami Kubo
the Department of Neurosurgery, Tokyo Women's Medical University
Tomokatsu Hori
the Department of Neurosurgery, Tokyo Women's Medical University
Kazue Takano
The Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University

Keywords: Cushing's disease, multiple bone fractures, young female, osteoporosis

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 9 Pages 583-587

DOI https://doi.org/10.2169/internalmedicine.46.1824

Details

Abstract

A 19-year-old woman who had decreased eight centimeters in stature was diagnosed as Cushing's disease with multiple spine compression fractures. At the age of 18, the patient had a complex fracture and gradually presented the features of Cushing's syndrome. Her plasma ACTH and cortisol levels were extremely high. Radiological findings and chemical markers for bone metabolism showed severe osteoporosis. Magnetic resonance imaging showed the presence of a pituitary microadenoma. After transsphenoidal surgery was performed, subsequently all endocrine data improved. This case indicates that Cushing's syndrome should be considered for severe osteoporotic juvenile patients.

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