Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Acquired Factor V Inhibitor Responsive to Corticosteroids in a Patient with Double Cancers
Hitoshi Endo, Kiyotaka Kawauchi, Masahiko Tomimatsu, Daijiro Iga, Toshie Ogasawara, Masako Yasuyama, Toshihito Saito, Kuniaki Otsuka, Motohiko Aiba
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Keywords: factor V inhibitor, HCV, liver cirrhosis, hepatocellular carcinoma, lung cancer
JOURNAL OPEN ACCESS

2007 Volume 46 Issue 9 Pages 621-625

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Abstract

A 70-year-old woman suffering from HCV-related liver cirrhosis was admitted for abnormal bleeding. Laboratory findings included PT at 46.6 sec, APTT at >212 sec, factor V activity of <3%, and factor V inhibitor of 2 BU. Having experienced a persistent bleeding tendency for one month, the patient was started on prednisolone (0.8 mg/kg/day). Within a few days, the inhibitor became undetectable and clinical bleeding disappeared. Although clinical improvement was achieved, she died 6 months after the initial bleeding episode from the progression of a lung cancer. An autopsy revealed squamous cell carcinoma of the lung and hepatocellular carcinoma.

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© 2007 by The Japanese Society of Internal Medicine
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