Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Recurrent Gefitinib-induced Interstitial Lung Disease
Masaru SuzukiHajime AsahinaJun KonishiKoichi YamazakiMasaharu Nishimura
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JOURNAL OPEN ACCESS

2008 Volume 47 Issue 6 Pages 533-536

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Abstract

Gefitinib, the epidermal growth factor receptor tyrosine kinase inhibitor, is effective for patients with non-small cell lung cancer. However, a serious adverse effect, interstitial lung disease (ILD), has been reported. The re-administration of gefitinib might be considered when there is no other choice of treatment and a therapeutic effect can be expected; however, there is no published data on the safety of restarting gefitinib after its discontinuation in cases suspected of having gefitinib-induced ILD. We report a case with recurrent gefitinib-induced ILD, which suggests that re-administration of gefitinib should be considered cautiously in patients who have previously developed gefitinib-induced ILD.

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© 2008 by The Japanese Society of Internal Medicine
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