Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Recurrence of Hepatitis-Associated Aplastic Anemia after a 10-year Interval
Tsuyoshi Muta, Yoshinori Tanaka, Eiji Takeshita, Yuichi Kobayashi, Takahito Tokuyama, Yoko Ueda, Koji Joko, Tomoaki Fujisaki, Eisuke Yokota
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Keywords: hepatitis-associated aplastic anemia, cyclosporine antithymocyte globulin
JOURNAL OPEN ACCESS

2008 Volume 47 Issue 19 Pages 1733-1737

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Abstract

Hepatitis-associated aplastic anemia (HAA) has been reported to show a successful outcome following immunosuppressive treatment. On the other hand, the long-term prognosis of HAA has not been sufficiently clarified. Herein we report a patient with HAA who had been treated with cyclosporine for one year, and maintained complete remission without treatment. Ten years later, acute non-A, non-B, and non-C hepatitis reccurred followed by bone marrow aplasia. A second immunosuppressive treatment with antithymocyte globulin and cyclosporine was effective. This case might provide useful information for the long-term follow-up of patients with HAA.

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© 2008 by The Japanese Society of Internal Medicine
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