Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
ORIGINAL ARTICLES
Heart Rate Variability and Hypercapnia in Duchenne Muscular Dystrophy
Hitoshi Mochizuki, Satomi Okahashi, Yoshikazu Ugawa, Takuhisa Tamura, Mikiya Suzuki, Satoko Miyatake, Toshiki Shigeyama, Katsuhisa Ogata, Mitsuru Kawai
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Keywords: Duchenne muscular dystrophy, hypercapnia, heart rate variability, coefficient of variation of the R-R interval
JOURNAL OPEN ACCESS

2008 Volume 47 Issue 21 Pages 1893-1897

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Abstract

Objective To investigate the relationship between heart rate variability and hypercapnia.
Patients and Methods We measured the coefficient of variation of R-R interval (CVrr) and arterial blood gas pressures in 73 patients with Duchenne muscular dystrophy.
Results CVrr was negatively correlated with arterial partial pressure of carbon dioxide (PaCO2). In patients whose CVrr was larger than 5%, 84% of them had no hypercapnia while the other 16% had hypercapnia (PaCO2 >45 mmHg). In contrast, 27% of those with CVrr smaller than 3% had no hypercapnia, 73% had hypercapnia and 47% had severe hypercapnia (PaCO2 >50 mmHg).
Conclusion We first showed that CVrr was negatively correlated with PaCO2, and propose that abnormally low CVrr indicates respiratory insufficiency in patients with Duchenne muscular dystrophy.

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© 2008 by The Japanese Society of Internal Medicine
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