Transformation of p53-Positive Papillary Thyroid Carcinoma to Anaplastic Carcinoma of the Liver following Postoperative Radioactive Iodine-131 Therapy

Yumie Takeshita; Toshinari Takamura; Hiroshi Minato; Hirofumi Misu; Hitoshi Ando; Tatsuya Yamashita; Hiroko Ikeda; Yasuni Nakanuma; Shuichi Kaneko

doi:10.2169/internalmedicine.47.1190

CASE REPORTS

Transformation of p53-Positive Papillary Thyroid Carcinoma to Anaplastic Carcinoma of the Liver following Postoperative Radioactive Iodine-131 Therapy

Yumie Takeshita, Toshinari Takamura, Hiroshi Minato, Hirofumi Misu, Hitoshi Ando, Tatsuya Yamashita, Hiroko Ikeda, Yasuni Nakanuma, Shuichi Kaneko

Author information

Yumie Takeshita
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science
Toshinari Takamura
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science
Hiroshi Minato
Pathology Section, Kanazawa University Hospital
Hirofumi Misu
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science
Hitoshi Ando
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science
Tatsuya Yamashita
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science
Hiroko Ikeda
Department of Human Pathology, Kanazawa University Graduate School of Medical Science
Yasuni Nakanuma
Department of Human Pathology, Kanazawa University Graduate School of Medical Science
Shuichi Kaneko
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science

Keywords: anaplastic transformation, differentiated thyroid carcinoma, iodine-131 therapy, p53 mutations, liver

JOURNAL OPEN ACCESS

2008 Volume 47 Issue 19 Pages 1709-1712

DOI https://doi.org/10.2169/internalmedicine.47.1190

Details

Abstract

Multiple liver metastases were incidentally detected in the lobe of the liver of an 81-year-old woman following total thyroidectomy and ablative radioactive iodine administration for the treatment of papillary thyroid carcinoma. A biopsy specimen taken from the metastatic liver tumor was histologically diagnosed as anaplastic carcinoma. Immunohistochemical staining for p53 was positive in both the primary tumor and liver biopsy specimens. We considered this to have been caused by anaplastic transformation from papillary thyroid carcinoma during treatment. We report a rare case of multiple liver metastases from a papillary thyroid carcinoma, which we believe to be the result of anaplastic transformation during postoperative radioactive iodine-131 therapy.

Corresponding author

Register with J-STAGE for free!