Paclitaxel-induced Interstitial Pneumonia after Drug-eluting Stent Implantation: Report of a Fatal Case

Kimihiko Kato; Satoshi Fukuda; Tetsuo Fujimaki; Yuko Takano; Eiji Kunii; Ken Kato; Kazuko Watanabe; Susumu Suzuki; Kiyoyasu Yamada; Kiyoshi Yokoi; Toshiyuki Mori

doi:10.2169/internalmedicine.48.1901

CASE REPORTS

Paclitaxel-induced Interstitial Pneumonia after Drug-eluting Stent Implantation: Report of a Fatal Case

Kimihiko Kato, Satoshi Fukuda, Tetsuo Fujimaki, Yuko Takano, Eiji Kunii, Ken Kato, Kazuko Watanabe, Susumu Suzuki, Kiyoyasu Yamada, Kiyoshi Yokoi, Toshiyuki Mori

Author information

Kimihiko Kato
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital
Satoshi Fukuda
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital
Tetsuo Fujimaki
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital
Yuko Takano
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital
Eiji Kunii
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital
Ken Kato
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital
Kazuko Watanabe
Department of Pathology, Gifu Prefectural Tajimi Hospital
Susumu Suzuki
Department of Internal Medicine, Gifu Social Insurance Hospital
Kiyoyasu Yamada
Department of Internal Medicine, Gifu Social Insurance Hospital
Kiyoshi Yokoi
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital
Toshiyuki Mori
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital

Keywords: paclitaxel-eluting stent, acute respiratory distress syndrome, autopsy

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 11 Pages 911-913

DOI https://doi.org/10.2169/internalmedicine.48.1901

Details

Abstract

We report a case of paclitaxel-eluting stent implantation in an angina patient who developed interstitial pneumonia a few days afterward, and succumbed to fatal respiratory dysfunction despite corticosteroid therapy. Paclitaxel is an anti-neoplastic agent currently used as a coating substance for coronary stents to reduce the rate of restenosis. Pulmonary toxicity related to paclitaxel is not very common; however, this adverse event may on occasion be lethal. Although the efficacy and safety of drug-eluting stents for the treatment of ischemic heart disease is well established, physicians should keep in mind that paclitaxel-eluting stents have the potential to cause interstitial pneumonia.

Corresponding author

Register with J-STAGE for free!