Synchronized Changes in Serum Vascular Endothelial Growth Factor during the Clinical Course of Chronic Systemic Capillary Leak Syndrome

Yoshiaki Kinoshita; Shunji Kasaoka; Motoki Fujita; Chiyomi Oshima; Yoshikatsu Kawamura; Ryosuke Tsuruta; Tsuyoshi Maekawa

doi:10.2169/internalmedicine.49.2929

CASE REPORTS

Synchronized Changes in Serum Vascular Endothelial Growth Factor during the Clinical Course of Chronic Systemic Capillary Leak Syndrome

Yoshiaki Kinoshita, Shunji Kasaoka, Motoki Fujita, Chiyomi Oshima, Yoshikatsu Kawamura, Ryosuke Tsuruta, Tsuyoshi Maekawa

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Keywords: systemic capillary leak syndrome, vascular endothelial growth factor, prednisolone, terbutaline, theophylline

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 8 Pages 791-794

DOI https://doi.org/10.2169/internalmedicine.49.2929

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Abstract

Systemic capillary leak syndrome (SCLS) is a rare disease characterized by leakage of plasma from blood vessels into the interstitial space due to increased capillary permeability. We describe a 24-year-old man who was hospitalized with systemic edema, hypoalbuminemia, and disseminated intravascular coagulation. After extensive investigative procedures, he was diagnosed with chronic SCLS and made a gradual recovery after starting on prednisolone, terbutaline, and theophylline. We measured the patient's serum vascular endothelial growth factor (VEGF) over time and found a relationship between serum VEGF and the clinical course.

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