Localized, Splenic, Diffuse Large B-Cell Lymphoma Presenting with Hypersplenism: Risk and Benefit of Splenectomy

Noriyoshi Iriyama; Akira Horikoshi; Yoshihiro Hatta; Yujin Kobayashi; Shigemasa Sawada; Jin Takeuchi

doi:10.2169/internalmedicine.49.3228

CASE REPORTS

Localized, Splenic, Diffuse Large B-Cell Lymphoma Presenting with Hypersplenism: Risk and Benefit of Splenectomy

Noriyoshi Iriyama, Akira Horikoshi, Yoshihiro Hatta, Yujin Kobayashi, Shigemasa Sawada, Jin Takeuchi

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Keywords: splenic diffuse large B-cell lymphoma, splenectomy, hypersplenism, high mortality

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 11 Pages 1027-1030

DOI https://doi.org/10.2169/internalmedicine.49.3228

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Abstract

Herein we report a case of a localized, massive, diffuse large B-cell splenic lymphoma diagnosed by splenectomy. A 57-year-old man complaining of weight loss and abdominal pain, was admitted to our hospital. Enhanced computed tomography scanning showed an irregularly enhanced effect in the spleen suggesting a diffuse splenic tumor. Splenectomy was done and the operation progressed without severe complications. The resected spleen weighed 3,500 g. After the operation, the patient recovered from the pancytopenia and pathology diagnosed diffuse large B-cell lymphoma. Standard CHOP plus rituximab chemotherapy was given. Complete remission has continued for 30 months.

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