Diffuse Liver Metastasis of Small Cell Lung Cancer Causing Marked Hepatomegaly and Fulminant Hepatic Failure

Hisamitsu Miyaaki; Tatsuki Ichikawa; Naota Taura; Mio Yamashima; Hideyuki Arai; Yoko Obata; Akira Furusu; Hiroko Hayashi; Shigeru Kohno; Kazuhiko Nakao

doi:10.2169/internalmedicine.49.3296

CASE REPORTS

Diffuse Liver Metastasis of Small Cell Lung Cancer Causing Marked Hepatomegaly and Fulminant Hepatic Failure

Hisamitsu Miyaaki, Tatsuki Ichikawa, Naota Taura, Mio Yamashima, Hideyuki Arai, Yoko Obata, Akira Furusu, Hiroko Hayashi, Shigeru Kohno, Kazuhiko Nakao

Author information

Hisamitsu Miyaaki
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences
Tatsuki Ichikawa
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences
Naota Taura
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences
Mio Yamashima
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences
Hideyuki Arai
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Yoko Obata
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Akira Furusu
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Hiroko Hayashi
Department of Investigative Pathology, Nagasaki University Graduate School of Biomedical Sciences
Shigeru Kohno
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Kazuhiko Nakao
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences

Keywords: small cell carcinoma, fulminant hepatic failure, hepatomegaly

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 14 Pages 1383-1386

DOI https://doi.org/10.2169/internalmedicine.49.3296

Details

Abstract

A 62-year-old female was admitted for examination of an abnormal liver function. Plain CT and MRI of the abdomen showed marked hepatomegaly but no visible nodular lesion in the liver. On the 3rd hospital day she had hepatic encephalopathy and was treated with a course of high-dose steroids, but ultimately died of disease progression on the 7th hospital day. An autopsy revealed a small pulmonary nodule with the histological findings showing small cell carcinoma. There was almost complete parenchymal replacement with metastatic tumor in the liver. Neoplastic involvement of the liver should be considered in the differential diagnosis of fulminant hepatic failure of unknown etiology.

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