A Case of Fever of Unknown Origin: Co-existence of Kikuchi-Fujimoto Disease and Acute Disseminated Encephalomyelitis (ADEM)

Vildan Avkan-Oguz; Nur Yapar; Serkan Ozakbas; Kubra Demir-Onder; Eray Aktas; Sema Alp-Cavus; Sermin Ozkal; Suleyman Men; Aydanur Kargi

doi:10.2169/internalmedicine.49.3633

CASE REPORTS

A Case of Fever of Unknown Origin: Co-existence of Kikuchi-Fujimoto Disease and Acute Disseminated Encephalomyelitis (ADEM)

Vildan Avkan-Oguz, Nur Yapar, Serkan Ozakbas, Kubra Demir-Onder, Eray Aktas, Sema Alp-Cavus, Sermin Ozkal, Suleyman Men, Aydanur Kargi

Author information

Vildan Avkan-Oguz
Department of Infectious Diseases and Clinical Microbiology, Dokuz Eylul University School of Medicine
Nur Yapar
Department of Infectious Diseases and Clinical Microbiology, Dokuz Eylul University School of Medicine
Serkan Ozakbas
Department of Neurology, Dokuz Eylul University School of Medicine
Kubra Demir-Onder
Department of Infectious Diseases and Clinical Microbiology, Dokuz Eylul University School of Medicine
Eray Aktas
Department of Infectious Diseases and Clinical Microbiology, Dokuz Eylul University School of Medicine
Sema Alp-Cavus
Department of Infectious Diseases and Clinical Microbiology, Dokuz Eylul University School of Medicine
Sermin Ozkal
Department of Pathology, Dokuz Eylul University School of Medicine
Suleyman Men
Department of Radiology, Dokuz Eylul University School of Medicine
Aydanur Kargi
Department of Pathology, Dokuz Eylul University School of Medicine

Keywords: fever of unknown origin (FUO), Kikuchi-Fujimoto disease, histiocytic necrotizing lymphadenitis, acute disseminated encephalomyelitis (ADEM)

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 16 Pages 1823-1826

DOI https://doi.org/10.2169/internalmedicine.49.3633

Details

Abstract

It is believed that viral infections and the hyperimmune reaction due to these infections are involved in the etiology of Kikuchi-Fujimoto Disease (KFD), a rare cause of fever of unknown origin. Axillary lymphadenopathy and neurologic involvement are rare in KFD. We present a patient diagnosed with KFD histopathologically during an investigation of the origin of fever and axillary lymphadenopathy. Subsequently, incidental sinus aspergilloma was diagnosed radiologically in the patient and acute disseminated encephalitis developed during follow-up. This report aims to draw attention to the co-existence of KFD and Acute Disseminated Encephalomyelitis, two diseases of which the origins are not clear.

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