Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Primary Bilateral Adrenal Diffuse Large B-cell Lymphoma Demonstrating Adrenal Failure
Kazuhiko Horiguchi, Koshi Hashimoto, Masayuki Hashizume, Takashige Masuo, Mariko Suto, Jun Okajo, Hiroshi Handa, Yoriaki Kaneko, Hideaki Yokoo, Atsushi Sasaki, Shuichi Okada, Masanobu Yamada, Norifumi Tsukamoto, Yoshihisa Nojima, Yoichi Nakazato, Masatomo Mori
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Keywords: bilateral adrenal tumor, diffuse B cell lymphoma, adrenal insufficiency
JOURNAL OPEN ACCESS

2010 Volume 49 Issue 20 Pages 2241-2246

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Abstract

Primary adrenal lymphoma (PAL) is extremely rare although involvement of malignant lymphoma into adrenals is common. We report a case of a 58-year-old man with bilateral PAL who demonstrated adrenal insufficiency. Primary large B-cell lymphoma was proven by a computed tomography-guided needle biopsy of the adrenal tumor. Although a complete remission was once achieved by combination chemotherapy plus rituximab, a recurrence occurred with brain metastasis leading to his death. We concluded that PAL should be considered as a possible cause of bilateral adrenal incidentalomas with progressive adrenal insufficiency.

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© 2010 by The Japanese Society of Internal Medicine
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