Hemophagocytic Syndrome in an Acute Human Immunodeficiency Virus Infection

Eisuke Adachi; Tomohiko Koibuchi; Kentaro Imai; Tadashi Kikuchi; Shoichi Shimizu; Michiko Koga; Hitomi Nakamura; Aikichi Iwamoto; Takeshi Fujii

doi:10.2169/internalmedicine.52.7544

CASE REPORTS

Hemophagocytic Syndrome in an Acute Human Immunodeficiency Virus Infection

Eisuke Adachi, Tomohiko Koibuchi, Kentaro Imai, Tadashi Kikuchi, Shoichi Shimizu, Michiko Koga, Hitomi Nakamura, Aikichi Iwamoto, Takeshi Fujii

Author information

Eisuke Adachi
Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Tomohiko Koibuchi
Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Kentaro Imai
Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Tadashi Kikuchi
Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan
Shoichi Shimizu
Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Michiko Koga
Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan
Hitomi Nakamura
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Japan
Aikichi Iwamoto
Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Japan
Takeshi Fujii
Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science, The University of Tokyo, Japan

Keywords: hemophagocytic syndrome, human immunodeficiency virus, acute HIV infection, antiretroviral therapy

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 5 Pages 629-632

DOI https://doi.org/10.2169/internalmedicine.52.7544

Details

Abstract

Hemophagocytic syndrome (HPS) is an unrecognized complication occurring in the acute stage of human immunodeficiency virus (HIV) infection that is seldom reported in the literature. We herein present a case of HPS that occurred during the seroconversion stage of HIV infection. In this case, pancytopenia and liver dysfunction related to HPS recovered after the initiation of antiretroviral therapy (ART). This report indicates the importance of early recognition of HPS and suggests that prompt initiation of ART has the potential to control HPS in the acute stage of HIV infection.

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