Elevated Fibrin-related Markers in Patients with Malignant Diseases Frequently Associated with Disseminated Intravascular Coagulation and Venous Thromboembolism

Yoshiki Yamashita; Hideo Wada; Hideki Nomura; Toshiro Mizuno; Kanako Saito; Norikazu Yamada; Kunihiro Asanuma; Masanobu Usui; Yuki Kamimoto; Takeshi Matsumoto; Kohshi Ohishi; Naoyuki Katayama

doi:10.2169/internalmedicine.53.1102

ORIGINAL ARTICLES

Elevated Fibrin-related Markers in Patients with Malignant Diseases Frequently Associated with Disseminated Intravascular Coagulation and Venous Thromboembolism

Yoshiki Yamashita, Hideo Wada, Hideki Nomura, Toshiro Mizuno, Kanako Saito, Norikazu Yamada, Kunihiro Asanuma, Masanobu Usui, Yuki Kamimoto, Takeshi Matsumoto, Kohshi Ohishi, Naoyuki Katayama

Author information

Yoshiki Yamashita
Departments of Hematology and Oncology, Mie University Graduate School of Medicine, Japan
Hideo Wada
Departments of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Japan
Hideki Nomura
Departments of Hematology and Oncology, Mie University Graduate School of Medicine, Japan
Toshiro Mizuno
Departments of Hematology and Oncology, Mie University Graduate School of Medicine, Japan
Kanako Saito
Departments of Hematology and Oncology, Mie University Graduate School of Medicine, Japan
Norikazu Yamada
Department of Cardiology, Mie University Graduate School of Medicine, Japan
Kunihiro Asanuma
Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Japan
Masanobu Usui
Departments of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Japan
Yuki Kamimoto
Departments of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Japan
Takeshi Matsumoto
Department of Blood Transfusion, Mie University Graduate School of Medicine, Japan
Kohshi Ohishi
Department of Blood Transfusion, Mie University Graduate School of Medicine, Japan
Naoyuki Katayama
Departments of Hematology and Oncology, Mie University Graduate School of Medicine, Japan

Keywords: malignant disease, DIC, VTE, D-dimer, SF

JOURNAL OPEN ACCESS

2014 Volume 53 Issue 5 Pages 413-419

DOI https://doi.org/10.2169/internalmedicine.53.1102

Details

Abstract

Objective Many patients with malignant diseases are frequently complicated with some type of thrombosis, such as venous thromboembolism (VTE) or disseminated intravascular coagulation (DIC).
Methods This retrospective study was designed to examine the frequency of thrombosis in 478 patients with malignant diseases in comparison to that observed in 121 patients without malignant diseases and to evaluate the efficacy of fibrin-related markers (FRMs), such as soluble fibrin, fibrinogen and fibrin degradation products and D-dimer, in diagnosing thrombosis.
Results The frequency of thrombosis, including 62 cases of VTE, 63 cases of DIC and nine cases of cerebrovascular thrombosis, was significantly higher in the patients with malignant diseases (28.0%) than in the patients without malignant diseases (12.5%). DIC was frequently detected in the patients with hepatic cell cancer and hematopoietic malignancy, while VTE was frequently observed in the patients with colon cancer, breast cancer and urinary tract cancer. The FRMs levels were significantly higher in the patients with thrombosis than in the patients without thrombosis. A receiver operating characteristic analysis showed these markers to be useful for diagnosing thrombosis.
Conclusion Patients with malignant diseases have a high risk of thrombosis, and elevated FRMs levels are useful for diagnosing thrombosis in patients with malignant diseases.

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