Three Cases of Concurrent Infection with Mycobacterium tuberculosis and Cryptococcus neoformans

Hiroshi Kakeya; Koichi Izumikawa; Koichi Yamada; Yoko Obata; Tomoya Nishino; Takahiro Takazono; Kosuke Kosai; Shintaro Kurihara; Shigeki Nakamura; Yoshifumi Imamura; Taiga Miyazaki; Misuzu Tsukamoto; Katsunori Yanagihara; Takayoshi Tashiro; Shigeru Kohno

doi:10.2169/internalmedicine.53.1281

CASE REPORTS

Three Cases of Concurrent Infection with Mycobacterium tuberculosis and Cryptococcus neoformans

Hiroshi Kakeya, Koichi Izumikawa, Koichi Yamada, Yoko Obata, Tomoya Nishino, Takahiro Takazono, Kosuke Kosai, Shintaro Kurihara, Shigeki Nakamura, Yoshifumi Imamura, Taiga Miyazaki, Misuzu Tsukamoto, Katsunori Yanagihara, Takayoshi Tashiro, Shigeru Kohno

Author information

Hiroshi Kakeya
Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Koichi Izumikawa
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Nagasaki University Infection Control and Education Center, Nagasaki University Hospital, Japan
Koichi Yamada
Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Yoko Obata
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Tomoya Nishino
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Takahiro Takazono
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Kosuke Kosai
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Shintaro Kurihara
Nagasaki University Infection Control and Education Center, Nagasaki University Hospital, Japan
Shigeki Nakamura
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Yoshifumi Imamura
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Taiga Miyazaki
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Misuzu Tsukamoto
Nagasaki University Infection Control and Education Center, Nagasaki University Hospital, Japan
Katsunori Yanagihara
Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan
Department of Laboratory Medicine, Nagasaki University Hospital, Japan
Takayoshi Tashiro
Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan
Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
Shigeru Kohno
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan

Keywords: pulmonary cryptococcosis, pulmonary tuberculosis, co-infection

JOURNAL OPEN ACCESS

2014 Volume 53 Issue 15 Pages 1685-1692

DOI https://doi.org/10.2169/internalmedicine.53.1281

Details

Abstract

Impaired cellular-mediated immunity is a known risk factor for both tuberculosis and cryptococcosis. However, pulmonary cryptococcosis associated with pulmonary tuberculosis is rare. We herein describe three cases of concurrent infection with Mycobacterium tuberculosis and Cryptococcus neoformans. All patients had underlying diseases; all three had uncontrolled diabetes mellitus, and other underlying diseases were liver cirrhosis, malignancy, and rheumatoid arthritis requiring long-term steroid use. We also review other relevant reports.

Corresponding author

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