Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens

Kazuya Okada; Akane Kunitomi; Kazuya Sakai; Hiroyuki Muranushi; Yusuke Okamoto; Taku Tsukamoto; Hiroyuki Sugiura; Hiroyuki Matsui; Tomoyasu Jo; Tomoaki Ueda; Tatsuhito Onishi; Masaru Ide; Shinya Kimura; Kenji Notohara; Yasunori Ueda

doi:10.2169/internalmedicine.54.2944

CASE REPORTS

Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens

Kazuya Okada, Akane Kunitomi, Kazuya Sakai, Hiroyuki Muranushi, Yusuke Okamoto, Taku Tsukamoto, Hiroyuki Sugiura, Hiroyuki Matsui, Tomoyasu Jo, Tomoaki Ueda, Tatsuhito Onishi, Masaru Ide, Shinya Kimura, Kenji Notohara, Yasunori Ueda

Author information

Kazuya Okada
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Akane Kunitomi
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Kazuya Sakai
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Hiroyuki Muranushi
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Yusuke Okamoto
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Taku Tsukamoto
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Hiroyuki Sugiura
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Hiroyuki Matsui
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Tomoyasu Jo
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Tomoaki Ueda
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Tatsuhito Onishi
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan
Masaru Ide
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Shinya Kimura
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Kenji Notohara
Department of Pathology, Kurashiki Central Hospital, Japan
Yasunori Ueda
Department of Hematology and Oncology, Kurashiki Central Hospital, Japan

Keywords: hairy cell leukemia, BRAF mutation, systemic lymphadenopathy

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 11 Pages 1397-1402

DOI https://doi.org/10.2169/internalmedicine.54.2944

Details

Abstract

A 47-year-old woman with pancytopenia, excessive systemic lymphadenopathy and splenomegaly was referred to our hospital. The peripheral blood (PB) smear findings indicated neutropenia with lymphoid cells exhibiting hairy projections, while the histological findings of the cervical lymph node (LN) suggested hairy cell leukemia (HCL). In addition, the BRAF V600E mutation was detected, and the immunoglobulin gene rearrangement patterns were identical in both the cervical LN and PB specimens. Based on these findings, we diagnosed the patient with systemic lymphadenopathy due to HCL. This is the first report of a BRAF mutation detected in both the PB and LN at the onset of HCL.

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