The Potential Role of Inflammation Associated with Interaction between Osteopontin and CD44 in a Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Breast Cancer

Akifumi Higashi; Yoshihiro Dohi; Naohiro Uraoka; Kazuhiro Sentani; Sayuri Uga; Hiroki Kinoshita; Yoshiharu Sada; Toshiro Kitagawa; Takayuki Hidaka; Satoshi Kurisu; Hideya Yamamoto; Wataru Yasui; Yasuki Kihara

doi:10.2169/internalmedicine.54.4749

CASE REPORTS

The Potential Role of Inflammation Associated with Interaction between Osteopontin and CD44 in a Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Breast Cancer

Akifumi Higashi, Yoshihiro Dohi, Naohiro Uraoka, Kazuhiro Sentani, Sayuri Uga, Hiroki Kinoshita, Yoshiharu Sada, Toshiro Kitagawa, Takayuki Hidaka, Satoshi Kurisu, Hideya Yamamoto, Wataru Yasui, Yasuki Kihara

Author information

Akifumi Higashi
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Yoshihiro Dohi
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Naohiro Uraoka
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Kazuhiro Sentani
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Sayuri Uga
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Hiroki Kinoshita
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Yoshiharu Sada
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Toshiro Kitagawa
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Takayuki Hidaka
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Satoshi Kurisu
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Hideya Yamamoto
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Wataru Yasui
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
Yasuki Kihara
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan

Keywords: pulmonary tumor thrombotic microangiopathy, pulmonary hypertension, osteopontin, CD44

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 22 Pages 2877-2880

DOI https://doi.org/10.2169/internalmedicine.54.4749

Details

Abstract

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare and fatal cancer-related complication. We herein present a case of PTTM that diagnosed antemortem by lung scintigraphy and pulmonary microvascular cytology. The patient was treated with steroid pulse therapy. Although her symptoms temporarily improved, she died of respiratory failure. An autopsy showed PTTM, and an immunohistochemical analysis revealed the expression of osteopontin and CD44 in macrophages that had migrated into the PTTM lesions. These findings suggest that inflammation associated with the interaction between osteopontin and CD44 may play an important role in PTTM.

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