Intravascular Large B-cell Lymphoma of the Bilateral Ovaries and Uterus in an Asymptomatic Patient with a t(11;22)(q23;q11) Constitutional Translocation

Yasuyuki Shigematsu; Motoki Matsuura; Noriko Nishimura; Naoko Tsuyama; Kengo Takeuchi; Yasuhito Terui; Nobuhiro Takeshima; Kiyohiko Hatake

doi:10.2169/internalmedicine.55.6578

CASE REPORTS

Intravascular Large B-cell Lymphoma of the Bilateral Ovaries and Uterus in an Asymptomatic Patient with a t(11;22)(q23;q11) Constitutional Translocation

Yasuyuki Shigematsu, Motoki Matsuura, Noriko Nishimura, Naoko Tsuyama, Kengo Takeuchi, Yasuhito Terui, Nobuhiro Takeshima, Kiyohiko Hatake

Author information

Yasuyuki Shigematsu
Division of Hematology Oncology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan
Division of General Oncology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan
Motoki Matsuura
Division of Gynecologic Oncology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan
Noriko Nishimura
Division of Hematology Oncology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan
Naoko Tsuyama
Division of Pathology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan
Kengo Takeuchi
Division of Pathology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan
Pathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research, Japan
Yasuhito Terui
Division of Hematology Oncology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan
Nobuhiro Takeshima
Division of Gynecologic Oncology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan
Kiyohiko Hatake
Division of Hematology Oncology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan

Keywords: IVLBCL, bilateral ovaries, uterus, t(11;22) constitutional translocation

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 21 Pages 3169-3174

DOI https://doi.org/10.2169/internalmedicine.55.6578

Details

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal diffuse large B-cell lymphoma, which is characterized by the intravascular growth of lymphoma cells, aggressive behavior, and an often fatal course. Patients with IVLBCL are usually symptomatic. Although any organ may be involved, localized lesions in the bilateral ovaries and uterus are extremely rare. We experienced a rare case of IVLBCL involving the bilateral ovaries and uterus in an asymptomatic patient with a t(11;22)(q23;q11) constitutional balanced translocation. Its association with the disease remains unknown. Even in asymptomatic situations, IVLBCL is possible, and the uterus and ovaries can be involved.

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