Japanese Man with HCV Genotype 4 Infection and Cirrhosis Who Was Successfully Treated by the Combination of Glecaprevir and Pibrentasvir

Mai Totsuka; Masayuki Honda; Tatsuo Kanda; Tomotaka Ishii; Naoki Matsumoto; Yoichiro Yamana; Tomohiro Kaneko; Taku Mizutani; Hiroshi Takahashi; Mariko Kumagawa; Reina Sasaki; Ryota Masuzaki; Shini Kanezawa; Kazushige Nirei; Hiroaki Yamagami; Shunichi Matsuoka; Hiroshi Ohnishi; Hiroaki Okamoto; Mitsuhiko Moriyama

doi:10.2169/internalmedicine.6728-20

CASE REPORTS

Japanese Man with HCV Genotype 4 Infection and Cirrhosis Who Was Successfully Treated by the Combination of Glecaprevir and Pibrentasvir

Mai Totsuka, Masayuki Honda, Tatsuo Kanda, Tomotaka Ishii, Naoki Matsumoto, Yoichiro Yamana, Tomohiro Kaneko, Taku Mizutani, Hiroshi Takahashi, Mariko Kumagawa, Reina Sasaki, Ryota Masuzaki, Shini Kanezawa, Kazushige Nirei, Hiroaki Yamagami, Shunichi Matsuoka, Hiroshi Ohnishi, Hiroaki Okamoto, Mitsuhiko Moriyama

Author information

Mai Totsuka
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Masayuki Honda
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Tatsuo Kanda
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Tomotaka Ishii
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Naoki Matsumoto
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Yoichiro Yamana
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Tomohiro Kaneko
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Taku Mizutani
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Hiroshi Takahashi
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Mariko Kumagawa
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Reina Sasaki
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Ryota Masuzaki
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Shini Kanezawa
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Kazushige Nirei
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Hiroaki Yamagami
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Shunichi Matsuoka
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan
Hiroshi Ohnishi
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan
Hiroaki Okamoto
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan
Mitsuhiko Moriyama
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan

Keywords: cirrhosis, DAA, HCV genotype 4, Japan, transfusion

JOURNAL OPEN ACCESS

2021 Volume 60 Issue 13 Pages 2061-2066

DOI https://doi.org/10.2169/internalmedicine.6728-20

Browse “Advance online publication” version

Details

Abstract

A 74-year-old man with a history of transfusion at 35 years old in Egypt was referred to our hospital. He was infected with hepatitis C virus (HCV) genotype 4 (GT4), which is a rare HCV GT in Japan, and was also diagnosed with hepatic compensated cirrhosis. We safely treated the patient for 12 weeks with the combination of glecaprevir and pibrentasvir, and a sustained virologic response (SVR) was achieved. This is the first report of HCV GT4 infection in a treatment-naïve Japanese patient with cirrhosis in whom SVR was achieved with the combination treatment of glecaprevir and pibrentasvir.

Corresponding author

Register with J-STAGE for free!