Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids

Fumika Honda; Hiroto Tsuboi; Hirofumi Toko; Ayako Ohyama; Hidenori Takahashi; Saori Abe; Masahiro Yokosawa; Hiromitsu Asashima; Shinya Hagiwara; Tomoya Hirota; Yuya Kondo; Isao Matsumoto; Takayuki Sumida

doi:10.2169/internalmedicine.9205-17

CASE REPORTS

Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids

Fumika Honda, Hiroto Tsuboi, Hirofumi Toko, Ayako Ohyama, Hidenori Takahashi, Saori Abe, Masahiro Yokosawa, Hiromitsu Asashima, Shinya Hagiwara, Tomoya Hirota, Yuya Kondo, Isao Matsumoto, Takayuki Sumida

Author information

Fumika Honda
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Hiroto Tsuboi
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Hirofumi Toko
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Ayako Ohyama
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Hidenori Takahashi
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Saori Abe
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Masahiro Yokosawa
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Hiromitsu Asashima
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Shinya Hagiwara
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Tomoya Hirota
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Yuya Kondo
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Isao Matsumoto
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
Takayuki Sumida
Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan

Keywords: Kikuchi-Fujimoto disease, histiocytic necrotizing lymphadenitis, hydroxychloroquine

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 24 Pages 3373-3377

DOI https://doi.org/10.2169/internalmedicine.9205-17

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Abstract

Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient.

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