Abstract
Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced apoptosis. A role of RIP is emphasized and novel mechanisms of FLIP-mediated inhibition of apoptosis are discussed. In addition, various mechanisms of TNF-induced activation of mitochondrial pathway of apoptosis have been reviewed.
Keywords: Tumor Necrosis Factor, Receptor-Mediated Apoptosis, Tumor necrosis factor (TNF-a), TNFRI, TRADD (TNF receptor-associated death-domain), TRAF-2, MAP kinase, NFkB
Current Molecular Medicine
Title: Molecular Steps of Tumor Necrosis Factor Receptor-Mediated Apoptosis
Volume: 1 Issue: 3
Author(s): S. Gupta
Affiliation:
Keywords: Tumor Necrosis Factor, Receptor-Mediated Apoptosis, Tumor necrosis factor (TNF-a), TNFRI, TRADD (TNF receptor-associated death-domain), TRAF-2, MAP kinase, NFkB
Abstract: Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced apoptosis. A role of RIP is emphasized and novel mechanisms of FLIP-mediated inhibition of apoptosis are discussed. In addition, various mechanisms of TNF-induced activation of mitochondrial pathway of apoptosis have been reviewed.
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Cite this article as:
Gupta S., Molecular Steps of Tumor Necrosis Factor Receptor-Mediated Apoptosis, Current Molecular Medicine 2001; 1 (3) . https://dx.doi.org/10.2174/1566524013363780
DOI https://dx.doi.org/10.2174/1566524013363780 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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