Abstract
Interleukin-7 (IL-7) is a cytokine that plays a critical role in T cell homeostasis by promoting proliferation and survival of mature T cells and also by enhancing thymic output for the generation of new T cells. IL-7 receptor expression and signaling function is perturbed in HIV infection and could contribute to disease pathogenesis. Even though highly active anti-retroviral therapy has markedly reduced morbidity and mortality in HIV-infected persons, there remains concern that a significant proportion of treated patients may experience relatively poor CD4+ T cell recovery despite sustained viral suppression. Recent human trials and animal studies suggest that IL-7 administration may provide a powerful tool to enhance T cell reconstitution in HIV-infected persons. The role of IL-7/IL-7 receptor perturbations in HIV pathogenesis and the potential to reconstitute immunity with IL-7 administration in the setting of HIV infection are important areas of investigation.
Keywords: HIV, interleukin-7, immune-based therapy, pathogenesis, T cell homeostasis, T cell reconstitution, CD4+, IL-7, receptor, FOXO3a
Current HIV Research
Title:Interleukin-7 Biology in HIV Disease and the Path to Immune Reconstitution
Volume: 10 Issue: 4
Author(s): Scott F. Sieg
Affiliation:
Keywords: HIV, interleukin-7, immune-based therapy, pathogenesis, T cell homeostasis, T cell reconstitution, CD4+, IL-7, receptor, FOXO3a
Abstract: Interleukin-7 (IL-7) is a cytokine that plays a critical role in T cell homeostasis by promoting proliferation and survival of mature T cells and also by enhancing thymic output for the generation of new T cells. IL-7 receptor expression and signaling function is perturbed in HIV infection and could contribute to disease pathogenesis. Even though highly active anti-retroviral therapy has markedly reduced morbidity and mortality in HIV-infected persons, there remains concern that a significant proportion of treated patients may experience relatively poor CD4+ T cell recovery despite sustained viral suppression. Recent human trials and animal studies suggest that IL-7 administration may provide a powerful tool to enhance T cell reconstitution in HIV-infected persons. The role of IL-7/IL-7 receptor perturbations in HIV pathogenesis and the potential to reconstitute immunity with IL-7 administration in the setting of HIV infection are important areas of investigation.
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Cite this article as:
F. Sieg Scott, Interleukin-7 Biology in HIV Disease and the Path to Immune Reconstitution, Current HIV Research 2012; 10 (4) . https://dx.doi.org/10.2174/157016212800792432
DOI https://dx.doi.org/10.2174/157016212800792432 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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