Treatment and Prognosis of Brain Metastases From Gynecological Cancers

Kazuhiko OGAWA; Yoshihiko YOSHII; Yoichi AOKI; Yutaka NAGAI; Yukihiro TSUCHIDA; Takafumi TOITA; Yasumasa KAKINOHANA; Wakana TAMAKI; Shiro IRAHA; Genki ADACHI; Makoto HIRAKAWA; Kazuya KAMIYAMA; Morihiko INAMINE; Akio HYODO; Sadayuki MURAYAMA

doi:10.2176/nmc.48.57

Original Articles

Treatment and Prognosis of Brain Metastases From Gynecological Cancers

Kazuhiko OGAWA, Yoshihiko YOSHII, Yoichi AOKI, Yutaka NAGAI, Yukihiro TSUCHIDA, Takafumi TOITA, Yasumasa KAKINOHANA, Wakana TAMAKI, Shiro IRAHA, Genki ADACHI, Makoto HIRAKAWA, Kazuya KAMIYAMA, Morihiko INAMINE, Akio HYODO, Sadayuki MURAYAMA

Author information

Kazuhiko OGAWA
Department of Radiology, University of the Ryukyus School of Medicine
Yoshihiko YOSHII
Department of Neurosurgery, University of the Ryukyus School of Medicine
Yoichi AOKI
Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
Yutaka NAGAI
Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
Yukihiro TSUCHIDA
Department of Neurosurgery, University of the Ryukyus School of Medicine
Takafumi TOITA
Department of Radiology, University of the Ryukyus School of Medicine
Yasumasa KAKINOHANA
Department of Radiology, University of the Ryukyus School of Medicine
Wakana TAMAKI
Department of Radiology, University of the Ryukyus School of Medicine
Shiro IRAHA
Department of Radiology, University of the Ryukyus School of Medicine
Genki ADACHI
Department of Radiology, University of the Ryukyus School of Medicine
Makoto HIRAKAWA
Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
Kazuya KAMIYAMA
Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
Morihiko INAMINE
Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
Akio HYODO
Department of Neurosurgery, University of the Ryukyus School of Medicine
Sadayuki MURAYAMA
Department of Radiology, University of the Ryukyus School of Medicine

Keywords: radiation therapy, brain metastasis, gynecological neoplasm, uterine cervical cancer, endometrial cancer, ovarian cancer

JOURNAL OPEN ACCESS

2008 Volume 48 Issue 2 Pages 57-63

DOI https://doi.org/10.2176/nmc.48.57

Details

Abstract

Brain metastases from gynecological cancers were retrospectively investigated in 18 patients who were treated between 1985 and 2006. Six patients received surgical resection followed by radiotherapy, and 12 patients received only radiotherapy. The median survival for all patients was 4.1 months (range 0.7-48.2 months), and the actuarial survival rates were 11% at both 12 months and 24 months. Univariate analysis showed that treatment modality, extracranial disease status, total radiation dose, number of brain metastases, and Karnofsky performance status (KPS) all had statistically significant impacts on survival. Two patients survived for more than 2 years, and both had single brain metastasis, inactive extracranial disease, 90-100% KPS, and were treated with surgical resection followed by radiotherapy. Improvements in neurological symptoms were observed in 10 of the 12 patients treated with palliative radiotherapy, with median duration of 3.1 months (range 1.5-4.5 months). The prognoses for patients with brain metastases from gynecological cancers were generally poor, although selected patients may survive longer with intensive brain tumor treatment. Palliative radiotherapy was effective in improving the quality of the remaining life for patients with unfavorable prognoses.

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