Fluorescent In Situ Hybridization 1p/19q Deletion/Imbalance Analysis of Low-Grade and Atypical Meningiomas

Toru NAGASAKA; Masaharu GUNJI; Noboru HOSOKAI; Kumiko HAYASHI; Masahiko FUJINO; Hiroshi IKEDA; Masafumi ITO; Suguru INAO

doi:10.2176/nmc.50.27

Original Articles

Fluorescent In Situ Hybridization 1p/19q Deletion/Imbalance Analysis of Low-Grade and Atypical Meningiomas

Toru NAGASAKA, Masaharu GUNJI, Noboru HOSOKAI, Kumiko HAYASHI, Masahiko FUJINO, Hiroshi IKEDA, Masafumi ITO, Suguru INAO

Author information

Toru NAGASAKA
Department of Neurosurgery, Japanese Red Cross Nagoya Daiichi Hospital
Masaharu GUNJI
Department of Pathology, Japanese Red Cross Nagoya Daiichi Hospital
Noboru HOSOKAI
Chromosome Testing Group, Molecular Genetic Testing Department, Clinical Testing Center, Mitsubishi Chemical Medience, Inc.
Kumiko HAYASHI
Chromosome Testing Group, Molecular Genetic Testing Department, Clinical Testing Center, Mitsubishi Chemical Medience, Inc.
Masahiko FUJINO
Department of Pathology, Japanese Red Cross Nagoya Daiichi Hospital
Hiroshi IKEDA
Department of Neurosurgery, Japanese Red Cross Nagoya Daiichi Hospital
Masafumi ITO
Department of Pathology, Japanese Red Cross Nagoya Daiichi Hospital
Suguru INAO
Department of Neurosurgery, Japanese Red Cross Nagoya Daiichi Hospital

Keywords: meningioma, fluorescent in situ hybridization, chromosome 1p/19q, chromosomal instability

JOURNAL OPEN ACCESS

2010 Volume 50 Issue 1 Pages 27-32

DOI https://doi.org/10.2176/nmc.50.27

Details

Abstract

The chromosomal 1p/19q state was analyzed in 16 low-grade meningiomas and 7 atypical meningiomas using fluorescent in situ hybridization (FISH) analysis. Chromosome 1p aberrations were observed in all atypical meningiomas, but in only one low-grade meningioma. Atypical meningiomas showed 19q deletion or imbalance, suggesting chromosomal instability of 19q. A small group of low-grade meningioma showed 19q aberrations. FISH 1p/19q deletion/imbalance analysis is a sensitive method for detecting chromosome aberrations of meningiomas and provides useful information for grading of meningiomas. Patients with low-grade meningioma with chromosomal instability of 1p/19q should be followed up carefully. Assessment of the chromosomal state by FISH might be of crucial importance in the clinical management of meningiomas.

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