The hOGG1 Ser326Cys Polymorphism Is Not Associated with Colorectal Cancer Risk

Hye-Won Park; Il-Jin Kim; Hio Chung Kang; Sang-Geun Jang; Sun-A Ahn; Jin Soo Lee; Hai-Rim Shin; Jae-Gahb Park

doi:10.2188/jea.17.156

Original Article

The hOGG1 Ser326Cys Polymorphism Is Not Associated with Colorectal Cancer Risk

Hye-Won Park, Il-Jin Kim, Hio Chung Kang, Sang-Geun Jang, Sun-A Ahn, Jin Soo Lee, Hai-Rim Shin, Jae-Gahb Park

Author information

Hye-Won Park
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University.
Il-Jin Kim
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University.
Hio Chung Kang
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University.
Research Institute and Hospital, National Cancer Center.
Sang-Geun Jang
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University.
Research Institute and Hospital, National Cancer Center.
Sun-A Ahn
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University.
Research Institute and Hospital, National Cancer Center.
Jin Soo Lee
Research Institute and Hospital, National Cancer Center.
Hai-Rim Shin
Research Institute and Hospital, National Cancer Center.
Jae-Gahb Park
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University.

Keywords: Clorectal Neoplasms, Polymorphism, Single Nucleotide, hOGG1, DNA Repair

JOURNAL FREE ACCESS

2007 Volume 17 Issue 5 Pages 156-160

DOI https://doi.org/10.2188/jea.17.156

Details

Abstract

BACKGROUND: Little is known about the genetic risk factors associated with colorectal cancer. Although the Ser326Cys polymorphism of 8-oxoguanine DNA glycosylase (hOGG1) is consistently associated with a range of cancers, there is no consensus regarding this polymorphism and colorectal cancer risk.
METHODS: In the present study, conducted in a Korean population, we used the TaqMan assay to investigate whether the hOGG1 Ser326Cys polymorphism was associated with colorectal cancer in 439 colorectal cancer patients and 676 healthy normal controls. We also examined whether the hOGG1 Ser326Cys polymorphism is associated with tumor location, microsatellite instability (MSI) status and tumor-node-metastasis (TNM) stage in colorectal cancer.
RESULTS: We found no significant difference between the cancer and control populations in terms of genotype distribution (CC, CG and GG). In addition, we found no association between the hOGG1 Ser326Cys polymorphism and cancer risk, MSI status, TNM stage or tumor location in colorectal cancer patients.
CONCLUSIONS: These results suggest that unlike for other cancer types, the hOGG1 Ser326Cys polymorphism is not a major genetic risk factor for colorectal cancer.
J Epidemiol 2007; 17: 156-160.

Corresponding author

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