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Comparison of standard coagulation tests and rotational thromboelastometry for hemostatic system monitoring during orthotopic liver transplantation: Results from a pilot study

Novaković-Anučin Slađana (Clinical Centre of Vojvodina, Centre of Laboratory Medicine, Novi Sad)
Kosanović Dušica (Clinical Centre of Vojvodina, Novi Sad, Department of Anesthesiology and Intensive Therapy)
Gnip Sanja (Clinical Centre of Vojvodina, Centre of Laboratory Medicine, Novi Sad)
Čanak Višnja (Clinical Centre of Vojvodina, Centre of Laboratory Medicine, Novi Sad)
Čabarkapa Velibor (Clinical Centre of Vojvodina, Centre of Laboratory Medicine, Novi Sad + Faculty of Medicine, Novi Sad)
Mitić Gorana (Clinical Centre of Vojvodina, Centre of Laboratory Medicine, Novi Sad + Faculty of Medicine, Novi Sad)

Introduction. During liver transplantation, continuous laboratory monitoring of complex changes of the hemostatic system is necessary. The aim of this study was to compare two methods of monitoring: standard coagulation tests and rotational thromboelastometry. Material and Methods. The study included 17 patients who had undergone orthotopic liver transplantation in the Clinical Centre of Vojvodina, Serbia in the period from June 2008 to October 2012. The coagulation parameters (platelet count, activated partial thromboplastin time, prothrombin time and fibrinogen level) were compared with the thromboelastometric parameters (coagulation time, clot formation time and maximal clot firmness). Results. The results showed a statistically significant correlation between the platelet count and maximum clot firmness of the intrinsically (r=0.51, p<0.001) and extrinsically activated thromboelastometric assays (r=0.64, p<0.001). The fibrinogen level and maximum clot firmness of the fibrinogen thromboelastometric test correlated significantly as well (r=0.44, p=0.002). No significant correlations were found among the activated partial thromboplastin time, prothrombin time, coagulation time and clot formation time. Conclusion. For an adequate perioperative monitoring of the dynamic intraoperative hemostatic changes and the optimal use of blood derivatives during liver transplantation, the combined application of standard coagulation tests and rotational thromboelastometry should be considered whenever possible. Science and Technological Development, Republic of Serbia

Keywords: Blood Coagulation Tests, Thromboelastography, Liver Transplantation, Hemostasis, Blood Chemical Analysis

Projekat Ministarstva nauke Republike Srbije, br. III 46005