Srpski arhiv za celokupno lekarstvo 2011 Volume 139, Issue 5-6, Pages: 291-297
https://doi.org/10.2298/SARH1106291A
Full text ( 265 KB)
Cited by
Keratocystic odontogenic tumour: An experience in the northeast of Brazil
Araújo Mello Leonardo (Laboratory of Oral Surgical Pathology, Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil)
Araújo Gurgel Silva Clarissa (Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil)
Ramos Gonçalves Antônio Eduardo (Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil)
de Souza Oliveira Renata (Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil)
Schlaepfer-Sales Brandi Caroline (Laboratory of Pathology and Molecular Biology, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil)
de Azevedo Almeida Roberto (Division of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil)
Santos Dos Nunes Jean (Laboratory of Oral Surgical Pathology, Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil)
Introduction. Keratocystic odontogenic tumours raise particular interest,
because of their high recurrence rate and association with nevoid basal cell
carcinoma syndrome. Objective. To analyze the clinical and histopathological
features of all cases diagnosed as keratocystic odontogenic tumour in a
Brazilian population. Methods. A total of 64 keratocystic odontogenic
tumours, arising in forty-six patients, were evaluated using the following
parameters: association with nevoid basal cell carcinoma syndrome, gender,
age at first diagnosis, race, anatomical location, symptoms, radiographic
features, history of recurrence, association with teeth, and treatment.
Results. Keratocystic odontogenic tumours were more frequent among women than
men (1:0.84). The mean patient age was 31.5 years (SD: ±16.6). Ten tumours
(16.4%) involved the maxilla and 51 (83.6%) the mandible. Swelling (n=12;
46.1%), followed by pain and swelling (n=4; 15.3%), were most common clinical
manifestations. A unilocular radiotransparency with well-defined margins was
the main radiographic finding (n=29; 87.8%). A significant association was
observed between the multilocular radiographic pattern and recurrence
(p<0.05, Fisher’s Test). Sixty-one (95.3%) tumours were treated by surgical
enucleation followed by bone curettage, and the recurrence rate was 13%
(n=6). This study showed that the keratocystic odontogenic tumours relapsed
within a mean period of 25-36 months. Conclusion. Despite the results of this
study being similar to previous reports found in the literature, it provides
an important insight about keratocystic odontogenic tumours in a Brazilian
population.
Keywords: epidemiology, odontogenic tumours, Brazilian population
More data about this article available through SCIndeks