Vojnosanitetski pregled 2011 Volume 68, Issue 11, Pages: 956-960
https://doi.org/10.2298/VSP100809001P
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The influence of probiotics on the cervical malignancy diagnostics quality
Perišić Živko (School of Medicine, Department for Early Cancer Detection, Gynecology and Obstetrics Clinic „Narodni front“, Belgrade)
Perišić Nataša (School of Medicine, Department for Early Cancer Detection, Gynecology and Obstetrics Clinic „Narodni front“, Belgrade)
Goločorbin-Kon Svetlana (School of Medicine, Department of Pharmacy, Novi Sad)
Vešović Dušan (School of Medicine, Department of Pharmacology and Toxicology, Novi Sad)
Mitrović-Jovanović Ana (School of Medicine, Department for Early Cancer Detection, Gynecology and Obstetrics Clinic „Narodni front“, Belgrade)
Mikov Momir (Belgrade’s Medical Center, Belgrade)
Background/Aim. Probiotics help to provide an optimum balance in the
intestines. Probiotics species competitive block toxic substances and growth
of unwanted bacteria and yeast species while they compete for the space and
food. Lactogyn® is the first oral probiotics on Serbian market dedicated to
maintaining a normal vaginal flora. Lactogyn® contains two well studied
probiotics strains - Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri
RC-14. Both of them are considered as probiotic agents with therapeutic
properties increase the population of beneficial lactobacillus organisms
within the vagina. The aim of this study was to exam an influence of
Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on results of
cervical smear cytological testing including detection of atypical cells,
detection of false positive and false negative findings as well as on
vaginal microflora content in patients with vaginal infection signs and
symptoms. Methods. Totally 250 women with signs of vaginal infection were
selected to participate in the study. The study group comprised 125 patients
taking studied probiotic strains along with specific anti-infective therapy.
The control group comprised, also, 125 patients taking anti-infective
agents, only. Probiotic preparation (Lactogyn ® capsules) was administered
orally (one capsule daily) during 4 weeks. Before and six weeks after
beginning of the therapy a cervical smear cytological test (the Papanicolaou
test), as well as microbiological examination of the vaginal smear were
performed. Results. Number of cases of inflammation and atypical squamous
cells of undeterminated significance (ASCUS) in the study group were
significantly higher before administration of the probiotic preparation. The
number of lactobacilli was significantly higher, and the number of
pathogenic microorganisms lower in the group treated with this preparation.
Conclusion. The application of probiotic strains Lactobacillus rhamnosus
GR-1 and Lactobacillus reuteri RC-14 concomitantly with specific
antiinfective agents provides more reliable cytological diagnostics, reduces
the number of false positive and false negative findings on cervical
malignancy and normalizes vaginal microflora in higher percentage of
patients with vaginal infections comapred with therapy including
anti-infective agents only.
Keywords: probiotics, Lactobacillus rhamnosus, lactobacillus reuteri, administration, oral, vaginal smears, treatment outcome
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