An Uncommon Case of Diabetic Mastopathy in Type II Non-Insulin Dependent Diabetes Mellitus

Keiichi Sotome; Tatsuya Ohnishi; Ryo Miyoshi; Makoto Nakamaru; Akio Furukawa; Hiroshi Miyazaki; Kyoei Morozumi; Yoichi Tanaka; Hisami Iri

doi:10.2325/jbcs.13.205

Case Reports

An Uncommon Case of Diabetic Mastopathy in Type II Non-Insulin Dependent Diabetes Mellitus

Keiichi Sotome, Tatsuya Ohnishi, Ryo Miyoshi, Makoto Nakamaru, Akio Furukawa, Hiroshi Miyazaki, Kyoei Morozumi, Yoichi Tanaka, Hisami Iri

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Keywords: Diabetic mastopathy, Lymphocytic lobulitis, Diabetes mellitus, Type II non-insulin dependent

JOURNAL FREE ACCESS

2006 Volume 13 Issue 2 Pages 205-209

DOI https://doi.org/10.2325/jbcs.13.205

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Abstract

Diabetic mastopathy is an uncommon tumor-like proliferation of fibrous tissue of the breast that usually occurs in a patient who has suffered from type I diabetes mellitus of long duration. Here we report a rare case of diabetic mastopathy that occurred in type II non-insulin dependent diabetes mellitus. This patient was a 63-year-old postmenopausal woman. Mammography, ultrasonography and MR imaging could not distinguish it from breast cancer. Although the core needle biopsy specimen showed fibrosis without evidence of malignancy, excisional biopsy was performed. Histological findings demonstrated typical diabetic mastopathy with keloid-like fibrosis, perivascular lymphocytic infiltration, and lymphocytic lobulitis without evidence of malignancy. These lymphocytes were composed predominantly of B-cells. Five months after surgical biopsy, a nodular formation approximately 4 cm in diameter recurred adjacent to the resected end of the biopsy.

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