ORIGINAL ARTICLE   

Panminerva Medica 2017 September;59(3):203-9

DOI: 10.23736/S0031-0808.17.03296-7

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The neutrophil/lymphocyte ratio is a better addition to C-reactive protein than CD64 index as a marker for infection in COPD

Raymond FARAH ^{1, 2}✉, Rabia IBRAHIM ¹, Majd NASSAR ¹, Dally NAJIB ^{2, 3}, Yifat ZIVONY ³, Elizabeth ESHEL ³

¹ Department of Internal Medicine B, Ziv Medical Center, Safed, Israel; ² Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel; ³ Hematology Institute, Ziv Medical Center, Faculty of Medicine, Bar Ilan University, Safed, Israel

BACKGROUND: This study investigated the importance of neutrophil/lymphocyte ratio (NLR) and other new inflammatory markers including CD64 expression in patients with chronic obstructive pulmonary disease (COPD) for identifying the severity of inflammation and recognition of acute exacerbation and infection.
METHODS: Seventy-two patients with a diagnosis of COPD exacerbation who were admitted to the Department of Internal Medicine B, 13 with stable COPD, and control group of 15 healthy people were enrolled in the study. Complete blood count (CBC), measurement of C-reactive protein (CRP), mean platelet volume (MPV), red blood cell distribution width (RDW) and CD64 expression were determined within 2 hours of hospital admission.
RESULTS: NLR and other inflammatory markers, such as RDW, CRP, and CD64 were found to be significantly elevated in exacerbated COPD compared to stable COPD and control participants. There was a significant correlation of NLR with CRP (r=0.309, P<0.001), For an NLR cutoff of 7.3, sensitivity for detecting exacerbation of COPD was 0.768 and specificity was 1-0.269 (AUC=0.793, P=0.001) RDW was significant as NLR. CD64 is statistically significant (P=0.002) the lack of significance was between acute exacerbation of COPD and stable COPD, but indexes were higher in the group of COPD patients with complications.
CONCLUSIONS: Elevated NLR can be used as a marker similar to CRP, and RDW, in the determination of increased inflammation in acutely exacerbated COPD. NLR could be beneficial for the early detection of potential acute exacerbations in patients with COPD who have normal levels of traditional markers; CD64 was higher but did not reach statistical significance. MPV was not helpful.

KEY WORDS: Chronic obstructive pulmonary disease - Biomarkers - Flow cytometry - IgG receptors - Symptom flare up