Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure

Enrico Tedeschi; Sirio Cocozza; Pasquale Borrelli; Lorenzo Ugga; Vincenzo Brescia Morra; Giuseppe Palma

doi:10.2463/mrms.cr.2016-0137

Case Reports

Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure

Enrico Tedeschi, Sirio Cocozza, Pasquale Borrelli, Lorenzo Ugga, Vincenzo Brescia Morra, Giuseppe Palma

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Keywords: gadolinium, magnetic resonance imaging contrast media, dentate nucleus, multiple sclerosis, relaxometry

JOURNAL OPEN ACCESS

2018 Volume 17 Issue 1 Pages 100-104

DOI https://doi.org/10.2463/mrms.cr.2016-0137

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Abstract

We report the assessment of Dentate Nuclei (DN) R1 (1/T₁) and R2* (1/T₂*) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric MR measurements within 2 years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes.

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