IMR Press / FBL / Volume 13 / Issue 12 / DOI: 10.2741/3038

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Muscular response and adaptation to diabetes mellitus
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1 Department of Endocrinology, ZhongDa hospital, Southeast University, Nanjing, People´s Republic of China
2 Department of Internal Medicine, ZhongDa hospital, Southeast University, Nanjing, People´s Republic of China
3 Section Sports and Rehabilitation Medicine, Department of Cardiology, University of Ulm, Ulm, Germany

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Landmark Ed) 2008, 13(12), 4765–4794; https://doi.org/10.2741/3038
Published: 1 May 2008
Abstract

Diabetes mellitus (DM) is an epidemic medical challenge that threatens the health and life quality of people worldwide. DM impairs metabolic, neural and vascular function and thus has profound impacts on different systems and organs in the body. Though continuous endeavour has been made to study its etiology and mechanisms, no cure for DM has yet been found. DM development may be multi-factorial. The skeletal muscle is one of the most important systems, involved in the development of DM, and affected by insulin. DM induces diverse functional, metabolic, and structural changes in the skeletal muscle. DM reduces the functional capacity of skeletal muscle leading to muscle weakness, causes metabolic disturbance characterized by reduced cellular glucose uptake and fatty acid oxidation, and structural changes with muscle atrophy, augmented lipid deposition, decreased mitochondria as well as muscle fiber transformation. DM-induced changes in the skeletal muscle seem to be dependent on types and severity of DM as well as on muscle fibers. The central mechanism underlying these changes is impaired insulin action in the skeletal muscle.

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