Fish Pathology
Online ISSN : 1881-7335
Print ISSN : 0388-788X
ISSN-L : 0388-788X
The Immunomodulatory Effects of Levamisole on Rainbow Trout, Oncorhynchus mykiss
Youichirou KAJITAMasahiro SAKAIShizuo ATSUTAMasanori KOBAYASHI
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JOURNAL FREE ACCESS

1990 Volume 25 Issue 2 Pages 93-98

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Abstract

The immunomodulatory effects of levamisole were investigated using rainbow trout, Oncorhynchus mykiss. Fish sampled 5 days after intraperitoneal injection of levamisole showed increased protection against Vibrio anguillarum when a single dose (0.5 mg/kg) was used. Phagocytic activity, chemiluminescence responses and natural killer cell activity in fish treated with levamisole were also increased, compared with those in the saline treated fish. Furthermore, levamisole activated the alternative complement pathway of rainbow trout, although serum bactericidal activities against V. anguillarum were not enhanced by the treatment of levamisole. These results indicate that levamisole has immunomodulatory effects in rainbow trout.

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© The Japanese Society of Fish Pathology
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