Journal of Clinical Biochemistry and Nutrition
Online ISSN : 1880-5086
Print ISSN : 0912-0009
ISSN-L : 0912-0009
Original Articles
Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients
Yoshihide Kimura, Takeshi Kamiya, Kyouji Senoo, Kenji Tsuchida, Atsuyuki Hirano, Hisayo Kojima, Hiroaki Yamashita, Yoshihiro Yamakawa, Nobuhiro Nishigaki, Tomonori Ozeki, Masatsugu Endo, Kazuhisa Nakanishi, Motoki Sando, Yusuke Inagaki, Michiko Shikano, Tsutomu Mizoshita, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka, Kohei Katsumi, Takashi Joh
Author information
Keywords: gastroesophageal reflux disease, health-related quality of life, 8-item Short Form Health Survey, Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale
JOURNAL FREE ACCESS

2016 Volume 59 Issue 1 Pages 71-77

Browse “Advance online publication” version
Details
Download PDF (448K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract

Some patients with gastroesophageal reflux disease experience persistent reflux symptoms despite proton pump inhibitor therapy. These symptoms reduce their health-related quality of life. Our aims were to evaluate the relationship between proton pump inhibitor efficacy and health-related quality of life and to evaluate predictive factors affecting treatment response in Japanese patients. Using the gastroesophageal reflux disease questionnaire, 145 gastroesophageal reflux disease patients undergoing proton pump inhibitor therapy were evaluated and classified as responders or partial-responders. Their health-related quality of life was then evaluated using the 8-item Short Form Health Survey, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale questionnaires. Sixty-nine patients (47.6%) were partial responders. These patients had significantly lower scores than responders in 5/8 subscales and in the mental health component summary of the 8-item Short Form Health Survey. Partial responders had significantly higher Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale scores, including anxiety and depression scores, than those of responders. Non-erosive reflux disease and double proton pump inhibitor doses were predictive factors of partial responders. Persistent reflux symptoms, despite proton pump inhibitor therapy, caused mental health disorders, sleep disorders, and psychological distress in Japanese gastroesophageal reflux disease patients.

Content from these authors
© 2016 JCBN
Previous article Next article
Favorites & Alerts

Recently viewed articles
Share this page
feedback
 Top