Inhibitory Effect of Long Term 1α-Hydroxyvitamin D3 Administration on Helicobacter pylori Infection

Akihiko Kawaura; Eiji Takeda; Noritoshi Tanida; Kimie Nakagawa; Hironori Yamamoto; Kenji Sawada; Toshio Okano

doi:10.3164/jcbn.38.103

Original Articles

Inhibitory Effect of Long Term 1α-Hydroxyvitamin D₃ Administration on Helicobacter pylori Infection

Akihiko Kawaura, Eiji Takeda, Noritoshi Tanida, Kimie Nakagawa, Hironori Yamamoto, Kenji Sawada, Toshio Okano

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Keywords: 1α-hydroxyvitamin D₃, Helicobacter pylori, pepsinogen I, elderly women, nursing home

JOURNAL FREE ACCESS

2006 Volume 38 Issue 2 Pages 103-106

DOI https://doi.org/10.3164/jcbn.38.103

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Abstract

The effects of long-term supplementation with 1α-hydroxyvitamin D₃ (1α (OH) D₃) on serum pepsinogen (PG) I levels, and Helicobacter pylori (H. pylori) infection rate, were investigated in healthy elderly women, aged 70 to 99 years, in a nursing home. Of these 34 subjects, 15 have been administered one microgram of 1α (OH) D₃ daily for twenty years, because of osteoporosis treatment, and 19 were free from the drug. Serum PG-I levels and H. pylori infection rate in subjects with 1α (OH) D₃ were significantly lower than those without treatment (p<0.05). These results suggested the inhibitory effect of long-term administration of 1α (OH) D₃ on H. pylori infection.

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