einstein (São Paulo). 19/Feb/2019;17(1):eRB4596.
Immunoinflammatory mediators in the pathogenesis of diabetes mellitus
Bárbara Festa Gomes
, Camila de Melo Accardo
DOI: 10.31744/einstein_journal/2019RB4596
ABSTRACT
Characterized as a metabolic syndrome with multiple consequences for the lives of patients, diabetes mellitus is also classified as a chronic non-communicable disease of great scope in the world. It is a complex disease, with different points of view, including the relation between inflammatory process, obesity and insulin resistance due to the performance of the various immunoinflammatory mediators – called adipokines – on glycemic homeostasis. Recent studies have precisely addressed this aspect for the development of drugs that assist in the protection of pancreatic ß cells from the damages arising from oxidative stress and inflammatory process, in order to control the hyperglycemic picture, which is characteristic of diabetes mellitus.
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