CCL4-Induced Hepatotoxicity: Study in Rats Intoxicated with Carbon Tetrachloride and Treated with Camel Milk and Urine

Abstract

The liver is responsible for the metabolism and detoxification of the most of components that enter the body. Carbon tetrachloride (CCl4) is a highly toxic chemical agent, the most famous drug used to induce liver damage experimentally. Camel milk has been deeply studied for its special properties because of its higher hepatoprotective, insulin and antibacterial activities. The present study was designed to examine the preventive effects of camel milk (CM) and camel urine against the toxic effects of acute exposure to carbon tetrachloride (CCl4) on the liver tissue of mice. Administration of a single dose of CCl4 caused liver toxicity as monitored by an increase in liver enzymes, including ALT, AST and ALP. A total of 24 albino rats (200–250 g) were divided randomly into 4 groups comprising 6 rats in each group, G1 The first group is untreated control, G2 was the positive CCl4, (G3) Rats fed with Camel milk (100 ml/24 h/cage) injected with CCl4, (G4) Rats fed with Camel Urine (100 ml/24 h/cage) injected with CCl4. A significant (P < 0.05) increase in serum AST, ALT, and ALP activities was observed in the CCl4-treated rats compared with those of the control rats, respectively. Based on this study, Camel milk and camel urine have a protective effect against CCL4-Induced Hepatotoxicity.