Multiple Skin Abscesses Caused by Rhizopus sp. Infection after Candida albicans Infection in an Immunocompromised Patient

Koji Makino; Jun Aoi; Sho Egashira; Noritoshi Honda; Yosuke Kubo; Yoko Kawakami; Hideyuki Hayashi; Takashi Mochizuki

doi:10.3314/mmj.18-00002

Short Reports

Multiple Skin Abscesses Caused by Rhizopus sp. Infection after Candida albicans Infection in an Immunocompromised Patient

Koji Makino, Jun Aoi, Sho Egashira, Noritoshi Honda, Yosuke Kubo, Yoko Kawakami, Hideyuki Hayashi, Takashi Mochizuki

Author information

Koji Makino
Department of Dermatology, National Hospital Organization Kumamoto Medical Center
Jun Aoi
Department of Dermatology, National Hospital Organization Kumamoto Medical Center
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University
Sho Egashira
Department of Dermatology, National Hospital Organization Kumamoto Medical Center
Department of Dermatology, Japanese Red Cross Kumamoto Hospital
Noritoshi Honda
Department of Dermatology, National Hospital Organization Kumamoto Medical Center
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University
Yosuke Kubo
Department of Dermatology, National Hospital Organization Kumamoto Medical Center
Department of Dermatology, National Sanatorium Kikuchi Keifuen
Yoko Kawakami
Department of Laboratory Medicine, National Hospital Organization Kumamoto Medical Center
Department of Laboratory Medicine, National Hospital Organization Kumamoto Saishunso National Hospital
Hideyuki Hayashi
Department of Laboratory Medicine, National Hospital Organization Kumamoto Medical Center
Takashi Mochizuki
Department of Dermatology, Kanazawa Medical University

Keywords: abscess, hepatic disorder, immunocompromised host, Rhizopus microsporus

JOURNAL FREE ACCESS

2019 Volume 60 Issue 1 Pages 17-21

DOI https://doi.org/10.3314/mmj.18-00002

Details

Abstract

A 66-year-old woman with diabetes who was treated with prednisolone (15 mg/day) for autoimmune hepatitis developed multiple erythematous nodules with retention of purulent fluid on her lower right limb. Candida albicans was cultured from the nodules. She was started on oral fluconazole, and the lesions subsided. However, multiple dark-red abscesses and indurations newly appeared on the left crus. Histopathological examination showed numerous branched hyphae, and tissue culture yielded a Rhizopus microsporus-related fungus. She was treated with liposomal amphotericin B combined with drainage and debridement. However, she died because of poor control of the infection and hepatic disorder.

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