Evaluation of anti-diarrheal activity of Diospyros malabarica bark extract
DOI:
https://doi.org/10.3329/bjp.v8i1.13157Keywords:
Castor oil, Diarrhea, Diospyros malabaricaAbstract
The present study was undertaken to evaluate the anti-diarrheal activity of the ethanolic extracts of Diospyros malabarica Kostel bark at concentration (200, 400 mg/kg) using different experimental model such as castor oil-induced diarrhea, gastrointestinal motility and enteropooling. The D. malabarica extract showed significant anti-diarrheal activity in a dose dependent manner. The results collectively demonstrate the D. malabarica could act by attributed to an anti-electrolyte permeability action, inhibit the PGE2 centrally and also anti-muscarinic activity to give anti-diarrheal effects. Result of charcoal meal test also suggested its anti-muscarinic activity. These findings indicate that ethanolic extract of the D. malabarica displays good anti-diarrheal activity, corroborating the folk use of D. malabarica preparations and contributing for its pharmacological validation.
Downloads
1797
1221 Read
520
References
Adeyemi OO, Akindele AJ. Anti-diarrheal activity of the ethyl acetate extract of Baphia nitida (Papilionaceae). J Ethnopharmacol. 2008; 116: 407-12.
Anonymous. Diarrhoeal disease control program. Weekly Epidemic Record. 1979; 16: 121.
Anonymous. Organization for Economic cooperation and development (OECD). OECD Guidelines for testing of chemicals acute oral toxicity. OECD, No. 425, 2008.
Choudhary DN, Singh JN, Verma SK, Singh BP. Antifertility effects of leaf extracts of some plants in male rats. Indian J Exp Biol. 1990; 28: 714-16.
Dajani E, Roge E, Bertrermann RE. Effects of E prostaglandins, dophenoxylate and morphine on intestinal motility in vitro. Euro J Pharmacol. 1975; 34: 105-13.
Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. Screening of Indian plants for biological activity: Part I. Indian J Exp Biol. 1968; 6: 232-47.
Helmut VA, Paul JT, Sidney FP. Effect of oleic and ricinoleic acids on net jejunal water and electrolyte moment perfusion studies in man. J Clin Invest. 1972; 53: 374-79.
Jayakumari S, Srinivasa Rao GH, Anbu J, Ravichandiran V. Anti-diarrheal activity of Dichrostachys cinerea (L.) Wight and Arn. Int J Pharm Sci. 2011; 3: 61-63.
Kalaskar MG, Divekar VB, Chaugule PD, Surana SJ, Baheti DG. Studies on anti-diarrheal activity of Dalberjia sissoo Roxb. in experimental animals. Pharmacologyonline 2010; 1: 453-57.
Mondal SK, Chakraborty G, Gupta M, Mazumder UK. Hepatoprotective activity of Diospyros malabarica bark in carbon tetrachloride intoxicated rats, European Bull Drug Res. 2005; 13: 25-30.
Swati B, Murugesan T, Sanghamitra S, Kuntal M, Jiaur RG, Pal M, Saha BP. Anti-diarrheal activity of Strychnos potatorum seed extract in rats. Fitoterapia 2002; 73: 43-47.
Warrier PK, Nambiar VPK, Ramankutty C. Indian medicinal plants: A compendium of 500 species. Part 2. Chennai, India, Orient Longman Ltd, 1994, p 336.
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
