The Effects of Prostaglandin Analogues on the Corneal Thickness.

Park, Myoung Hee; Cho, Kyongjin; Moon, Jung Il

doi:2009.50.4.565

J Korean Ophthalmol Soc > Volume 50(4); 2009 > Article

Original Article

Journal of the Korean Ophthalmological Society 2009;50(4):565-571.
DOI: https://doi.org/10.3341/jkos.2009.50.4.565 Published online April 30, 2009.

The Effects of Prostaglandin Analogues on the Corneal Thickness.

Myoung Hee Park, Kyongjin Cho, Jung Il Moon

Department of Ophthalmology, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. jimoon@catholic.ac.kr

프로스타글란딘 제제의 장기 점안이 각막두께에 미치는 영향

박명희ㆍ조경진ㆍ문정일

Department of Ophthalmology, St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea

Abstract

PURPOSE
To evaluate the effects of prostaglandin analogues on the corneal thickness of patients with primary open-angle glaucoma (POAG) or normal tension glaucoma (NTG). METHODS: This study included 130 eyes of 65 patients who were diagnosed with POAG or NTG. All patients were divided into two groups; one group received prostaglandin analogues, while the other group received alternative ocular hypotensive eyedrops. Corneal thickness, best corrected visual acuity, and flare in the anterior chamber were measured and compared before treatment and at least 24 months (mean: 27 months) after treatment. RESULTS: The mean decrease in corneal thickness was statistically significant in the group using prostaglandin analogues, but not in the control group. Among the various prostaglandin analogues used, travoprost and latanoprost decreased mean corneal thickness, but bimatoprost had no effect. Best corrected visual acuity, refraction power, and flare in the anterior chamber did not change significantly in either group of patients when ocular hypotensive eyedrops were used. CONCLUSIONS: Prostaglandin analogues lower intraocular pressure and decrease corneal thickness if used over a 24 months.

Key Words: Corneal thickness;Prostaglandin analogue