Yonsei Med J. 2002 Feb;43(1):128-132. English.
Published online Apr 01, 2009.
https://doi.org/10.3349/ymj.2002.43.1.128
Published online Apr 01, 2009.
https://doi.org/10.3349/ymj.2002.43.1.128
Copyright © 2002 The Yonsei University College of Medicine
Original Article
Successful Treatment of Cisplatin Overdose with Plasma Exchange
Jae Hyuck Choi,1
Jane C. Oh,1
Kang Ho Kim,1
So Young Chong,1
Myoung Seo Kang,2
and DoYeun Oh1
Abstract
We report a 48-year-old man with laryngeal cancer who received a massive cisplatin toxic overdose without intravenous prehydration through an error in prescription. He received 400 mg/m2 of cisplatin over a 4-day period. On day 4, he exhibited a broad range of cisplatin toxicities and emergency plasma exchange was started. From day 5 through 19, he underwent 9 cycles of plasma exchange and his plasma cisplatin concentration decreased from 2,470 ng/ml to 216 ng/ml. He completely recovered without any sequelae. No previous reports exist in the English literature of survival without complication after the administration of such a high cisplatin dosage without prehydration.
Keywords
Cisplatin overdose; plasma exchange
MeSH Terms
Permalink information copied to clipboard