Safety Profile of Extractive from Trunk of Salacia reticulate (Celastraceae)

Hiroshi SHIMODA; Takashi FUJIMURA; Kohei MAKINO; Kenichi YOSHIJIMA; Kazuyoshi NAITOH; Hiromi IHOTA; Yoshihisa MIWA

doi:10.3358/shokueishi.40.3_198

Safety Profile of Extractive from Trunk of Salacia reticulate (Celastraceae)

Hiroshi SHIMODA, Takashi FUJIMURA, Kohei MAKINO, Kenichi YOSHIJIMA, Kazuyoshi NAITOH, Hiromi IHOTA, Yoshihisa MIWA

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Keywords: salacia extractive, Salacia reticulata, single dose oral toxicity study, chromosomal aberration test, mutagenicity

JOURNAL FREE ACCESS

1999 Volume 40 Issue 3 Pages 198-205_1

DOI https://doi.org/10.3358/shokueishi.40.3_198

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Abstract

The safety profile of an extractive from Salacia reticulata (Celastraceae) trunk (SE) was examined using an oral single dose toxicity test and chromosomal aberration test. In the oral toxicity test, SD rats were given SE at a dose of 5, 000mg/kg. No deaths or abnormalities in gross pathological findings were observed during the study period. The rats given SE had diarrhea for a few days due to the pharmacological properties. Moreover, body weight gain was suppressed in both male and female rats given SE, compared to the controls, at 1 day after administration. In the chromosomal aberration test using cultured mammalian cells (CHL/IU), no cells with chromosomal aberrations were observed. These results suggest that SE has no serious acute toxicity or mutagenicity.

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