The purpose of this study was to examine the daily skeletal muscle hypertrophic and strength responses to one week of twice daily KAATSU training, and follow indicators of muscle damage and inflammation on a day-to-day basis, for one subject. KAATSU training resulted in a 3.1% increase in muscle-bone CSA after 7 days of training. Both MRI-measured maximum quadriceps muscle cross-sectional area (Q-CSA max) and muscle volume can be seen increasing after the first day of KAATSU training, and continuously increasing for the rest of the training period. Following 7 days KAATSU resistance training, the increases in Q-CSA max and muscle volume were 3.5% and 4.8%, respectively. Relative strength (isometric knee extension strength per unit Q-CSA max) was increased after training (before, 3.60 Nm/cm²; after, 4.09 Nm/cm²). There were very modest increases in CK and myoglobin after a single bout of KAATSU exercise in the first day of the training, but the values were return towards normal at 2 days after the training. IL-6 remained unchanged throughout the training period. In conclusion, our subject gained absolute strength and increased muscle size after only one week of low intensity KAATSU resistance training. Indicators of muscle damage and inflammation were not elevated by this training. KAATSU training appears to be a safe and effective method to rapidly induce skeletal muscle strength and hypertrophy.