Association between Helicobacter pylori infection and overweight or obesity in a Chinese population

Authors

  • Yan Zhang Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Tingting Du Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Xi Chen Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Xuefeng Yu Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Ling Tu Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Cuntai Zhang Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

DOI:

https://doi.org/10.3855/jidc.6035

Keywords:

Helicobacter pylori infection, body mass index, overweight, obesity

Abstract

Introduction: Recent studies found that Helicobacter pylori (H. pylori) infection plays a role in cardiometabolic disorders. The objective of this study was to assess the association between H. pylori infection and overweight or obesity in a Chinese population.

Methodology: A cross-sectional analysis using data from the subjects who underwent a health examination between January 2010 and June 2012 in the department of comprehensive medicine was performed. Diagnosis of H. pylori infection was achieved using the carbon urea breath test (14C-UBT). The participants were divided into H. pylori infection-positive group and H. pylori infection-negative group by 14C-UBT.

Results: A total of 2,050 subjects were enrolled in the study. The H. pylori infection-positive group had significantly higher body mass index (BMI) levels than did the H. pylori infection-negative group (25.32 vs 24.95, p = 0.008). There was a positive association between H. pylori infection and BMI levels (β = 0.30 ± 0.12, p = 0.015). After additional adjustment for white blood cell count (WBCC), the statistical significance disappeared (β = 0.24 ± 0.12, p = 0.053). Furthermore, a positive association between H. pylori infection and overweight/obesity according to different BMI criteria (BMI ≥ 24, BMI ≥ 23) was found. However, the association between H. pylori infection and obesity was consistently significant only based on the Asian criteria (BMI ≥ 27.5), but not significant based on the Chinese criteria (BMI ≥ 28).

Conclusion: H. pylori infection was significantly and positively associated with overweight/obesity in a Chinese population.

Author Biographies

Yan Zhang, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Department of Comprehensive Medicine

Tingting Du, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Department of Endocrinology

Xi Chen, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Department of Endocrinology

Xuefeng Yu, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Department of Endocrinology

Ling Tu, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Department of Comprehensive Medicine

Cuntai Zhang, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Department of Comprehensive Medicine

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Published

2015-09-27

How to Cite

1.
Zhang Y, Du T, Chen X, Yu X, Tu L, Zhang C (2015) Association between Helicobacter pylori infection and overweight or obesity in a Chinese population. J Infect Dev Ctries 9:945–953. doi: 10.3855/jidc.6035

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Section

Original Articles