Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study123
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From the Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Science, Tehran, Iran (TE and AH); the Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran (TE, HP, MS, and RM); and the Gastroenterology and Liver Disease Research Center, Firoozgar Hospital, Tehran University of Medical Sciences, Tehran, Iran (FZ).
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Supported by the National Nutrition and Food Technology Research Institute of the Shahid Beheshti University and the Digestive Disease Research Institute of the Shariati Hospital. Protexin Company, UK, provided the synbiotic supplements, and Nikan Teb Co provided the FibroScan machine.
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Address correspondence to A Hekmatdoost, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Science, 7 No, West Arghavan Street, Farahzadi Boulevard, PO Box 19395-4741, Tehran, Iran 1981619573. E-mail: [email protected]; and H Poustchi, Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Shariati Hospital, PO Box 14117-13135, Tehran, IR Iran. E-mail: [email protected].
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Abbreviations used: ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; FBS, fasting blood sugar; GGT, γ-glutamyltransferase; MET, metabolic equivalent of task; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; NF-κB, nuclear factor κ-B; PBMC, peripheral blood mononuclear cell; WHR, waist-to-hip ratio.