Effect of n−3 PUFA supplementation on cognitive function throughout the life span from infancy to old age: a systematic review and meta-analysis of randomized controlled trials1234
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From the Chronic Disease Research Institute, Department of Nutrition, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
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Supported by the National Natural Science Foundation of China (grant no. 31201307) and Zhejiang Provincial Natural Science Foundation of China (grant no. LY14C200008).
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Supplemental Methods, Supplemental Tables 1–10, and Supplemental Figures 1–13 are available from the “Supplemental data” link in the online posting of the article and from the same link in the online table of contents at http://ajcn.nutrition.org.
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Address correspondence to S Zhu, Chronic Disease Research Institute, Department of Nutrition, School of Public Health, School of Medicine, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. E-mail: [email protected].
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Abbreviations used: AD, Alzheimer disease; ADAS-Cog, Cognitive Subscale of the Alzheimer Disease Assessment Scale; LCPUFA, long-chain PUFA; MDI, Mental Development Index; MMSE, Mini-Mental State Examination; PDI, Psychomotor Development Index; RCT, randomized controlled trial; SMD, standardized mean difference.